Synthetic urea refers to the urea that is produced artificially as distinguished from biosynthetic or natural urea.
It is an industrial product that has found many applications but primarily as nitrogen fertilizer.
Also described as synthetic or chemical fertilizer, it is an organic compound that is manufactured following an industrial process independent of living organisms.
Natural and manufactured urea have the same chemical formula CO(NH2)2.
However, natural urea is produced by living organisms, specifically, humans, other mammals, and other ureotelic organisms (excretes most nitrogen as urea; Mathews and Van Holde 1990) and subsequently excreted mostly in the urine.
Pure urea was isolated from urine many years ago.